The Europa League knockout round play-off draw took place at UEFA headquarters in Nyon, Switzerland, on Monday 7 November. The results of it are as follows:

Barcelona vs Manchester United
Juventus vs Nantes
Sporting CP vs Midtjylland
Shakhtar Donetsk vs Rennes
Ajax vs Union Berlin
Bayer Leverkusen vs Monaco
Sevilla vs PSV Eindhoven
Salzburg vs Roma

The first legs of the ties are scheduled for February 16 2023, with the second on February 23.