The UEFA Europa League knockout round play-offs feature 16 teams: the eight runners-up from the Europa League group stage and the eight third-placed teams from the UEFA Champions League group stage.

Seeded teams
Freiburg (GER)
Marseille (FRA)
Rennes (FRA)
Roma (ITA)
Qarabağ (AZE)
Sparta Praha (CZE)
Sporting CP (POR)
Toulouse (FRA)

Unseeded teams
Benfica (POR)
Braga (POR)
Feyenoord (NED)
Galatasaray (TUR)
Lens (FRA)
Milan (ITA)
Shakhtar Donetsk (UKR)
Young Boys (SUI)

The Europa League knockout round play-off draw takes place at UEFA headquarters in Nyon, Switzerland, on Monday 18 December.